THe TOP 10 of 2025
For more information, click your desired startup.
1st Place: Valoon GmbH
Business: Construction
Location: Dortmund


1st Place: Valoon GmbH
Valoon is the first chat for construction projects – simple, secure and directly in WhatsApp.Valoon brings all project participants together in a central, construction-specific chat that is directly integrated into WhatsApp. The aim is to digitize communication on the construction site, make information available more quickly and make collaboration more efficient.
2nd Place: ChemInnovation GmbH
Business: Chemistry & AI
Location: Münster


2nd Place: ChemInnovation GmbH
No matter if it’s pharma, specialty chemicals or perfume – they all face the same challenge: identifying unknown substances. The question “Which molecules are in my sample?” spans all of chemistry. GC-MS devices help, but produce complex spectrometric data, which can only be interpreted manually by experts – a slow and costly process. ChemInnovation develops chemically inspired AI and cheminformatics algorithms to automate this. Their product METIS, developed at the University of Münster, analyzes GC-MS data fully automatically in under 5 minutes, improving speed 5–20× and increasing identification rates by 50–200% – while needing less expertise and delivering high-quality results across a wide range of applications.
3rd Place: comuneo
Business: GovTech
Location: Münster


3rd Place: comuneo
Comuneo is a digital platform for planning, managing and implementing municipal measures. It is aimed at cities, municipalities and public institutions and enables data-based management of municipal processes – from strategy development to concrete implementation and evaluation. Comuneo promotes transparent collaboration between administration, politics and the public and helps municipalities to work more efficiently and in a more targeted manner. The aim is to provide digital solutions for modern, sustainable and citizen-oriented local government.
ARQUE Systems GmbH
Business: Quantum technologies
Location: Aachen


ARQUE Systems GmbH
ARQUE Systems GmbH is a spin-off from Forschungszentrum Jülich and RWTH Aachen University, specializing in the development and commercialization of advanced quantum computing systems based on electron spins in silicon. Their patented, highly scalable qubit architecture addresses key challenges associated with scaling up quantum computers to achieve significant real-world advantages. The founding team combines decades of experience in semiconductor qubit technology, with backgrounds from prestigious institutions such as Harvard University, Stanford University, and the University of Cambridge. ARQUE Systems aims to revolutionize the quantum computing hardware market by delivering superior quantum chip technology that offers robust qubit quality, high operation speed, and seamless integration with scalable on-chip cryogenic control electronics.
DNTOX GmbH
Business: Biotech
Location: Düsseldorf


DNTOX GmbH
DNTOX GmbH is a German bioanalytical testing laboratory specializing in animal-free screening of chemicals for their potential to disrupt human brain development, focusing on developmental neurotoxicity (DNT). Their in vitro testing battery utilizes human cell models and incorporates artificial intelligence-based chemical screening through proprietary software. DNTOX offers services in developmental neurotoxicity testing, adult neurotoxicity testing, and computational biology and bioinformatics.
Gizil GmbH
Business: Energy and Industry
Location: Düsseldorf


Gizil GmbH
Gizil GmbH advances industrial digitalization through Virtual Plant (VP), a revolutionary digital twin platform combining AI with point cloud data technology. This innovation democratizes advanced digital technologies, making sophisticated digital twin capabilities accessible and affordable for German industry. The solution particularly addresses the digitalization gap in traditional industrial sectors, strengthening global competitiveness through practical, agile implementation of Industry 4.0 principles.
LastBIM GmbH
Business: ConTech
Location: Essen


LastBIM GmbH
LastBIM digitizes the construction process from planning to execution. Our platform offers an easy way to manage building information efficiently and improve collaboration in construction projects – all in an open and vendor-neutral system.
minimum energy GmbH
Business: Clean tech
Location: Cologne


minimum energy GmbH
Minimum provides a software solution for corporate decarbonization.
With our platform, companies can analyze, reduce, and report CO₂ emissions – automated, standards-compliant, and integrated into existing systems. Our goal: radically simplifying climate action.
SpotmyEnergy
Business: Energy Management, Renewable Power Supply, Smart Metering
Location: Cologne


SpotmyEnergy
SpotmyEnergy integrates metering point operation and electricity trading to create an innovative network of flexible power consumers and PV power producers. The company develops and deploys smart meters alongside sophisticated optimization systems for energy consumption, production, and trading. This integrated solution enables customers to maintain complete control over their energy management through simple, accurate, and profitable tools. By replacing legacy analog infrastructure with digital solutions, SpotmyEnergy facilitates optimal energy resource management.
Storyboarder.ai
Business: Film
Location: Dortmund


Storyboarder.ai
Storyboarder is your AI-powered co-creator for film, TV, and commercials. Generate complete, ready-to-shoot storyboards in minutes.